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Generic Name: metronidazole, dosage Form: tablet, film coated, extended release, show On This Page. View All, show On This Page, to reduce the development of drug-resistant bacteria and flagyl insomnia maintain the effectiveness of Flagyl ER, and other antibacterial drugs, Flagyl ER should be used only to treat or prevent infections that are proven or strongly suspected to be caused. Metronidazole has been shown to be carcinogenic in mice and rats (see. Unnecessary use of the drug should be avoided. Its use should be reserved for flagyl insomnia conditions described in the. Indications AND usage section below. Flagyl ER Description, flagyl metronidazole flagyl insomnia extended release tablets is an oral formulation of the synthetic nitroimidazole antimicrobial agent, which has the following structural formula: flagyl (metronidazole) extended release tablets, 750 mg (indicated below as Flagyl ER) contain 750 mg of metronidazole USP. Inactive ingredients include hypromellose, lactose, magnesium stearate, polyethylene glycol, poly (meth) acrylic acid ester copolymers, polysorbate 80, silicon dioxide, simethicone emulsion, talc, titanium dioxide, FD C Blue. Flagyl ER - Clinical Pharmacology, absorption. Disposition of metronidazole in the body is similar for both oral and intravenous dosage forms. Flagyl ER 750 mg tablets contain 750 mg of metronidazole in an extended release formulation which allows for once-daily dosing. The steady state pharmacokinetics were determined in 24 healthy adult female subjects with a mean SD age.8.8 years (range: 1946).2 The pharmacokinetic parameters of metronidazole after flagyl insomnia administration of Flagyl ER 750 mg under fed and fasting conditions are summarized in the following. Steady State Pharmacokinetic Parameters of Metronidazole after 750 mg of Flagyl ER Given Once a Day for 7 Days. Flagyl ER 750 mg daily MeanSD (N24). Parameter fed fasted, aUC(024) (ghr/mL) 21160.0 19875.3, cmax (g/mL).220.127.116.11, cmin (g/mL).18.104.22.168, tmax flagyl insomnia (hrs).22.214.171.124, t (hrs).126.96.36.199, relative to the fasting state, the rate of metronidazole absorption from the extended release tablet is increased in the fed state resulting. Metronidazole is the major component appearing in the plasma, with lesser quantities of metabolites also being present. Less than 20 of the circulating metronidazole is bound to plasma proteins. Metronidazole appears in cerebrospinal fluid, saliva, and breast milk in concentrations similar to those found in plasma. Bactericidal concentrations of metronidazole have also been detected in pus from hepatic abscesses. Metabolism/Excretion, the major route of elimination of metronidazole and its metabolites is via the urine (60 to 80 of the dose with fecal excretion accounting for 6 to 15 of the dose. The metabolites that appear in the urine result primarily from side-chain oxidation and acid and glucuronide conjugation, with unchanged metronidazole accounting for approximately 20 of the total. Both the parent compound and the hydroxyl metabolite possess in vitro antimicrobial activity. Renal clearance of metronidazole is approximately 10 mL/min/1.73.1 The average elimination half-life of metronidazole in healthy subjects is eight hours. Renal Impairment, decreased renal function does not alter the single-dose pharmacokinetics of metronidazole. Subjects with end-stage renal disease (esrd; clcr8.19.1mL/min) and who received a single intravenous infusion of metronidazole 500 mg had no significant change in metronidazole pharmacokinetics but had 2-fold higher Cmax of hydroxy-metronidazole and 5-fold higher Cmax of metronidazole acetate, compared to healthy subjects with normal. Thus, on account of the potential accumulation of metronidazole metabolites in esrd patients, monitoring for metronidazole associated adverse events is recommended (see. Effect of Dialysis Following a single intravenous infusion or oral dose of metronidazole 500 mg, the clearance of metronidazole was investigated in esrd subjects undergoing hemodialysis or continuous ambulatory peritoneal dialysis (capd). A hemodialysis session lasting for 4 to 8 hours removed 40 to 65 of the administered metronidazole dose, depending on the type of dialyzer membrane used and the duration of the dialysis session. If the administration of metronidazole cannot be separated from the dialysis session, supplementation of metronidazole dose following hemodialysis should be considered (see dosage AND administration ). A peritoneal dialysis session lasting for.5 hours removed approximately 10 of the administered metronidazole dose. No adjustment in metronidazole dose is needed in esrd patients undergoing capd.
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